Manga Helpers: These guys offer scanlations of comics that aren't available in the U.S., and it even has forums where you can talk with other fans.
DDR:UK: My favorite resource site for Dance Dance Revolution.
Nanaca Crash: Very addictive Flash game where you're a character who got booted into the air by someone's bike, and you have to try to control where you land (and on whom).
DVD Profiler: Use this to organize your DVDs and make your collection searchable. Awesome!
ListenToYouTube.com: If you like a song or need a sound clip from something on YouTube, you can translate it into an mp3 you can download here.
TV Tropes: Chronicles the many patterns and clichés of fiction of all types (despite the "TV" reference in the name). So addictive that in some places on the Internet you're required to warn people if you're posting a TV Tropes link since it often results in the loss of hours.
FOOD:
Chef2Chef: A chef's practical guide to practically everything.
Supercook.com: Find recipes that use ingredients you have at home!
The Cook's Thesaurus: A cooking encyclopedia that covers thousands of ingredients and kitchen tools. Entries include pictures, descriptions, synonyms, pronunciations, and suggested substitutions.
Food Conversion Charts: Great for translating that overseas recipe into your local measurements.
Urban Dictionary: You can find out what all those stupid things people say mean if you're just too out of touch to know every single piece of slang on the planet.
LITERATURE:
Storycode.com: You can code stories here, and by the codes, figure out what other stories you might like based on the similarities others have identified. Very innovative.
Goodreads: You can join, make a profile, rate and review your favorite books, and get a friends list going so you can have your friends' reading habits and recommendations mailed to you!
The Wayback Machine: Use this site to type in any URL and find out what it used to look like at any particular time. This is especially useful if a dead page used to have great content and you can't get it anymore; it might be archived here and saved after all!
SKEPTICISM/SCIENCE:
Skeptic's Annotated Bible: Notes for understanding the Bible, mainly to point out contradictions and absurdities.
Pharyngula: Some of the best biologically oriented and snarkily skeptic articles around. This guy is quite a joy to read.
Skepchick.org: A nice blend of science, skepticism, and feminism that I love to read.
RichardDawkins.net: This English biologist has great ideas and has contributed much to science.
SamHarris.org: I appreciate Sam Harris's views on faith and religion when balanced with science. He has a very healthy view of skepticism and seeking the TRUTH.
Limyaael's Fantasy Rants: Fantasy writers (and any kind of writer in some general sense) will need to avoid doing some of these things that annoy Limyaael. Because if you avoid these things, you will be a much better writer.
Authonomy: Run by HarperCollins, this is a site where serious authors can post fiction--preferably whole novels--and, through a rating system and promotion and whatnot, can end up getting it read by an editor at this major publisher. Skip the slush pile!
Duotrope's Digest: a database of over 2000 current markets for short fiction, poetry, and novels/collections.